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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10285 | ALK inhibitor 1 | FAK , IGF-1R , ALK | |
ALK inhibitor 1 is a selective ALK kinase inhibitor. | |||
T11184 | EML4-ALK kinase inhibitor 1 | EML4 ALK kinase inhibitor 1,EML4-ALK kinase inhibitor 1 | ALK |
EML4-ALK kinase inhibitor 1 (EML4 ALK kinase inhibitor 1) is a potent oral active inhibitor of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), with an IC50 of 1 nM. | |||
T6409 | ALK kinase inhibitor-1 | SAR348830 | Others |
SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase. | |||
T3059 | ALK-IN-1 | AP26113,Brigatinib,AP26113-analog | EGFR , IGF-1R , ALK |
ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2. | |||
T11254 | F-1 | ROS , ALK , ROS Kinase | |
F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathwa... | |||
T4015 | HG-14-10-04 | ALK | |
HG-14-10-04 is a potent and specific ALK inhibitor. | |||
T2641 | KRCA-0008 | KRCA 0008,KRCA0008 | ACK , ALK |
KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability. | |||
T16708 | R-268712 | ALK , TGF-beta/Smad | |
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor inhibitor. | |||
T2251 | NVP-TAE 684 | TAE684 | Apoptosis , ALK |
NVP-TAE 684 (TAE684) is a excellently effective and specific ALK inhibitor(IC50=3 nM). | |||
T67699L | ALK/ROS1 inhibitor 2e HCL | (R)-1-(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(trifluoromethoxy)benzyl)piperidine-3-carboxamide hydrochloride(2365497-12-5 Free base) | Apoptosis |
ALK/ROS1 inhibitor 2e HCL possesses anti-apoptotic, anti-proliferative and anti-tumour activities. | |||
T3678 | Entrectinib | RXDX-101,NMS-E628 | Trk receptor , ROS , ALK , Autophagy , ROS Kinase |
Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C-ros oncogene 1 (ROS1; IC50: 0.2 nM). Entrectini... | |||
T8387 | Alectinib hydrochloride | CH5424802 (Hydrochloride),AF-802 (Hydrochloride),RO5424802 (Hydrochloride) | ALK |
Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM) | |||
T1936 | Alectinib | RG-7853,AF802,CH5424802,AF-802 | VEGFR , Tyrosine Kinases , ALK |
Alectinib (RG-7853) is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. | |||
T3061 | Lorlatinib | PF-6463922,PF-06463922,Loratinib | Apoptosis , Tyrosine Kinases , ROS , ALK , ROS Kinase |
Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), with potential antineoplastic activity. | |||
T8399 | Crizotinib hydrochloride | PF-02341066 hydrochloride | c-Met/HGFR , ROS , ALK , Autophagy , ROS Kinase |
Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM) | |||
T10286 | ALK/ROS1-IN-1 | Others | |
ALK/ROS1-IN-1 is a potent and selective anti-crizotinib-resistant ALK/ROS1 dual inhibitor (IC50s: 0.530 μM and 0.174 μM for ROS1 and ALK enzyme). | |||
T73417 | Con B-1 | ||
ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells . | |||
T61443 | Trk-IN-7 | ||
Trk-IN-7 (compound I-6) is a highly potent inhibitor of TRK, exhibiting IC50 values ranging from 0.25-10 nM for TRKA, TRKB, and TRKC, respectively. In addition, Trk-IN-7 demonstrates notable inhibition against EML4-ALK (... | |||
T83146 | ALK-IN-27 | ||
ALK-IN-27 (compound 1) is a potent ALK inhibitor exhibiting antitumor activity, with an IC50 of 2.7 nM in Ba/F3 CLIP1-LTK cells [1]. | |||
T72931 | TRK/ALK-IN-1 | ||
TRK/ALK-IN-1 is a potent dual inhibitor of TRK and ALK, exhibiting good correlation between its enzymatic inhibition and anti-proliferative activities, with IC50 values of 2.2 nM for TRKA, 9.3 nM for ALK WT, and 38 nM fo... |